Vitamin B12 (Hydroxocobalamin)
Vitamin B12 is an important water-soluble vitamin that is involved in red blood cell production, brain health, and DNA synthesis. A deficiency in Vitamin B12 can cause serious Symptoms, including fatigue, digestive issues and neurological problems like depression and memory loss.
Fortified breakfast cereals
Fortified nutritional yeasts
Normal functioning of the brain and nervous system
Cognitive functioning (ability to think)
Formation of red blood cells and anaemia prevention
Helping create and regulate DNA
Possibly preventing congenital abnormalities
Helping protect the eyes from macular degeneration
Necessary for energy production
Vitamin B12 is normally involved in several metabolisms such as DNA synthesis and regulation, fatty acid synthesis, and energy production. Vitamin B12 had been usually treated as sport nutrition, and used to prevent elderly people from getting anaemic in past years. Vitamin B12 was regarded as painkilling vitamin in some countries from 1950. Recently studies have shown that vitamin B12 played a key role in the normal functioning of the brain and nervous system and the formation of blood. Vitamin B12 has some analogues including cyanocobalamin (CNCbl), methylcobalamin (MeCbl), hydroxocobalamin (OHCbl), and adenosylcobalamin (AdoCbl). Co-methylcobalmin is a coenzyme of methionine synthase, which is required for the formation of methionine from homocysteine in the methylation cycle which involves methylation of DNA or proteins. Compared with other analogues, Co-methylcobalamin is the most absorbable by subcellular organelles of neurons. Therefore, it may provide better treatments for nervous disorders through effective systemic or local delivery (1). Vitamin B12 is essential for healthy blood. When the body does not have enough B12, it leads to decreased normal red blood cell production (anemia), which impairs oxygen delivery. Megaloblastic anemia, also called nutritional-deficiency anemia, is a type of anemia caused by B12 or folate deficiency. Megaloblastic anemia is characterized by impaired DNA synthesis and the formation of large, abnormal, immature red blood cells. In normal pregnancy, B12 levels fall by 30% by the third trimester of pregnancy (2). As B12 plays as important role in new tissue development, deficiency can be associated with infertility and repeated miscarriage (3). Untreated B12 has been associated with adverse neurological outcomes in exclusively breastfed infants (4).
Products with Vitamin B12 (Hydroxocobalamin)
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Where are Ultra Nature products manufactured?
All of our vitamins and supplements are designed, tested, approved and manufactured in Australia.
Are all Ultra Nature Products TGA Approved?
Ultra Nature Products are Approved by the TGA where required, and, if so, carry an Aust L number on front of the product packaging.
The only product in our range that is not TGA approved is the Ultra Nature Propolis and Manuka Honey Oral Spray.
This product is classified as a food supplement due to the Manuka Honey Content, hence it does not require TGA Approval.
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What age group is suitable to consume an adult dose?
As per TGA guidelines, an adult dose is suitable for individuals 18 years and older.
How should I store my vitamins and supplements?
We recommend referring to the label for safe storage guidance. In general, with any supplement, it is always recommend that you store them at an average room temperature of 25°C and you must not store them in direct sunlight or near heat.
1. Zhang, Ming et al. “Methylcobalamin: a potential vitamin of pain killer.” Neural plasticity vol. 2013 (2013): 424651. doi:10.1155/2013/424651
2. Guidelines for the diagnosis and treatment of cobalamin and folate disorders – Devalia – 2014 – British Journal of Haematology – Wiley Online Library https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.12959
3. Khan, A., & Robinson, S. (2018). Vitamin B12 and Folate Deficiencies in Pregnancy. In S. Pavord & B. Hunt (Eds.), The Obstetric Hematology Manual (pp. 29-39). Cambridge: Cambridge University Press. doi:10.1017/9781316410837.006 Vitamin B12 and Folate Deficiencies in Pregnancy (Chapter 4) – The Obstetric Hematology Manual (cambridge.org)
4. Vitamin and mineral supplementation in pregnancy (ranzcog.edu.au)